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The purpose of this article is to determine the disproportions of the development of the regions of Ukraine and establishing common characteristics in the processes of spreading the latest information and communication technologies. This will determine the prospects for the formation of a knowledge economy in the country. The method of generalization and systematization, cluster analysis and cartography were used to determine the object of research. The clustering of the regions of Ukraine for the conditions of 2009 and 2018 years proceeded. Five homogeneous clusters were identified that differ in the degree of dissemination of information and telecommunication technologies. This was characterized by different levels of willingness for the formation of the knowledge economy in a separate region and the whole country. There were established vectors for the strategic development of the regions of Ukraine for each cluster that are directed at the spreading of information and telecommunication technologies. They serve as a key tool for the formation of the knowledge economy in the country. There were also substantiated the possible results from the implementation of measures to improve the functioning of the country in this field of activity.