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The stem bark of Ficus sycomorus is used traditionally for cure of fungal infection, jaundice and dysentery in some parts of northern Nigeria. The leaves of Ficus sycomorus were collected, dried and extracted to screen for some phytochemicals and study its effect on liver and kidney functions in experimental rats. Phytochemical screening of leaf extract of F. sycomorus indicates the presence of alkaloids, tannins, saponins, flavonoids and reducing sugars. Animals were divided into two sets (A&B) of five groups each and were administered 0.00, 200, 400, 800 and 1600 mgkg-1 body weight of the aqueous leaf extract for 14 days orally with set A administered once daily and set B administered twice daily. Serum activities of ALT, AST, ALP and concentration of urea and creatinine of both sets show no significant difference (p< 0.05) compared to the control group; except in ALP (148.00±0.77 and 175.80±0.45 U/L) and urea (41.20±0.09 and 53.38±0.17 mg/dL) at higher doses (1600mgkg-1) of the extract. Base on this study, the extract show neither liver nor kidney toxicity, however, it should be use with caution especially at higher dose and long time exposure.