作者
Xiaoju Wang, Jianjun Yu, Arun Sreekumar, Sooryanarayana Varambally, Ronglai Shen, Donald Giacherio, Rohit Mehra, James E Montie, Kenneth J Pienta, Martin G Sanda, Philip W Kantoff, Mark A Rubin, John T Wei, Debashis Ghosh, Arul M Chinnaiyan
发表日期
2005/9/22
期刊
New England Journal of Medicine
卷号
353
期号
12
页码范围
1224-1235
出版商
Massachusetts Medical Society
简介
Background
New biomarkers, such as autoantibody signatures, may improve the early detection of prostate cancer.
Methods
With a phage-display library derived from prostate-cancer tissue, we developed and used phage protein microarrays to analyze serum samples from 119 patients with prostate cancer and 138 controls, with the samples equally divided into training and validation sets. A phage-peptide detector that was constructed from the training set was evaluated on an independent validation set of 128 serum samples (60 from patients with prostate cancer and 68 from controls).
Results
A 22-phage-peptide detector had 88.2 percent specificity (95 percent confidence interval, 0.78 to 0.95) and 81.6 percent sensitivity (95 percent confidence interval, 0.70 to 0.90) in discriminating between the group with prostate cancer and the control group. This panel of peptides performed better than did prostate-specific …
引用总数
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X Wang, J Yu, A Sreekumar, S Varambally, R Shen… - New England Journal of Medicine, 2005