作者
Diane E Dickel, Jeremy Veenstra-VanderWeele, Nancy J Cox, Xiaolin Wu, Daniel J Fischer, Michelle Van Etten-Lee, Joseph A Himle, Bennett L Leventhal, Edwin H Cook, Gregory L Hanna
发表日期
2006/7/1
期刊
Archives of general psychiatry
卷号
63
期号
7
页码范围
778-785
出版商
American Medical Association
简介
Context
The first 2 independent linkage studies for obsessive-compulsive disorder (OCD) identified a region on 9p24 with suggestive evidence for linkage. The glutamate transporter gene solute carrier family 1, member 1 (SLC1A1) is a promising functional candidate in this region because altered glutamatergic concentrations have been found in the striatum and anterior cingulate in neuroimaging studies of pediatric OCD.
Objective
To determine whether genotypes at polymorphisms in theSLC1A1gene region are associated with early-onset OCD.
Design
Family-based analysis of association using the transmission disequilibrium test, confirmed using the family-based association test.
Setting
Anxiety disorders program in an academic medical center.
Participants
Seventy-one probands withDSM-III-RorDSM-IVOCD and their parents.
Methods
Nine single nucleotide polymorphisms spaced throughout theSLC1A1gene …
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DE Dickel, J Veenstra-VanderWeele, NJ Cox, X Wu… - Archives of general psychiatry, 2006