作者
Michael J Gandal, Pan Zhang, Evi Hadjimichael, Rebecca L Walker, Chao Chen, Shuang Liu, Hyejung Won, Harm Van Bakel, Merina Varghese, Yongjun Wang, Annie W Shieh, Jillian Haney, Sepideh Parhami, Judson Belmont, Minsoo Kim, Patricia Moran Losada, Zenab Khan, Justyna Mleczko, Yan Xia, Rujia Dai, Daifeng Wang, Yucheng T Yang, Min Xu, Kenneth Fish, Patrick R Hof, Jonathan Warrell, Dominic Fitzgerald, Kevin White, Andrew E Jaffe, PsychENCODE Consortium, Mette A Peters, Mark Gerstein, Chunyu Liu, Lilia M Iakoucheva, Dalila Pinto, Daniel H Geschwind
发表日期
2018/12/14
期刊
Science
卷号
362
期号
6420
页码范围
eaat8127
出版商
American Association for the Advancement of Science
简介
INTRODUCTION
Our understanding of the pathophysiology of psychiatric disorders, including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD), lags behind other fields of medicine. The diagnosis and study of these disorders currently depend on behavioral, symptomatic characterization. Defining genetic contributions to disease risk allows for biological, mechanistic understanding but is challenged by genetic complexity, polygenicity, and the lack of a cohesive neurobiological model to interpret findings.
RATIONALE
The transcriptome represents a quantitative phenotype that provides biological context for understanding the molecular pathways disrupted in major psychiatric disorders. RNA sequencing (RNA-seq) in a large cohort of cases and controls can advance our knowledge of the biology disrupted in each disorder and provide a foundational resource for integration with …
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MJ Gandal, P Zhang, E Hadjimichael, RL Walker… - Science, 2018