作者
Mingfeng Li, Gabriel Santpere, Yuka Imamura Kawasawa, Oleg V Evgrafov, Forrest O Gulden, Sirisha Pochareddy, Susan M Sunkin, Zhen Li, Yurae Shin, Ying Zhu, André MM Sousa, Donna M Werling, Robert R Kitchen, Hyo Jung Kang, Mihovil Pletikos, Jinmyung Choi, Sydney Muchnik, Xuming Xu, Daifeng Wang, Belen Lorente-Galdos, Shuang Liu, Paola Giusti-Rodríguez, Hyejung Won, Christiaan A De Leeuw, Antonio F Pardiñas, BrainSpan Consortium†, PsychENCODE Consortium†, PsychENCODE Developmental Subgroup†, Ming Hu, Fulai Jin, Yun Li, Michael J Owen, Michael C O’Donovan, James TR Walters, Danielle Posthuma, Mark A Reimers, Pat Levitt, Daniel R Weinberger, Thomas M Hyde, Joel E Kleinman, Daniel H Geschwind, Michael J Hawrylycz, Matthew W State, Stephan J Sanders, Patrick F Sullivan, Mark B Gerstein, Ed S Lein, James A Knowles, Nenad Sestan
发表日期
2018/12/14
期刊
Science
卷号
362
期号
6420
页码范围
eaat7615
出版商
American Association for the Advancement of Science
简介
INTRODUCTION
The brain is responsible for cognition, behavior, and much of what makes us uniquely human. The development of the brain is a highly complex process, and this process is reliant on precise regulation of molecular and cellular events grounded in the spatiotemporal regulation of the transcriptome. Disruption of this regulation can lead to neuropsychiatric disorders.
RATIONALE
The regulatory, epigenomic, and transcriptomic features of the human brain have not been comprehensively compiled across time, regions, or cell types. Understanding the etiology of neuropsychiatric disorders requires knowledge not just of endpoint differences between healthy and diseased brains but also of the developmental and cellular contexts in which these differences arise. Moreover, an emerging body of research indicates that many aspects of the development and physiology of the human brain are not well …
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M Li, G Santpere, Y Imamura Kawasawa, OV Evgrafov… - Science, 2018