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OBJECTIVE:

To assess a cluster of risk factors, including parameters of the metabolic syndrome, in women with gestational diabetes mellitus (GDM) early after delivery, that features the best prediction for developing diabetes.

METHODS:

Women with GDM 3–6 months after delivery received a complete metabolic characterization at baseline as well as annually for up to 10 years of follow-up (N= 110). We used parameters characterizing the metabolic syndrome as well as demographic variables at baseline to predict diabetes manifestation.

RESULTS:

Metabolic disturbances and insulin treatment during pregnancy were significantly associated with overt diabetes. Waist circumference of 80 cm or higher failed to show a significant effect on later development of the disease; however, it was significant when 88 cm or more was used as a cutoff value. We identified impaired glucose tolerance (13 [56.5%]; hazard ratio 6.77 …