作者
Nils Rostoks, Luke Ramsay, Katrin MacKenzie, Linda Cardle, Prasanna R Bhat, Mikeal L Roose, Jan T Svensson, Nils Stein, Rajeev K Varshney, David F Marshall, Andreas Graner, Timothy J Close, Robbie Waugh
发表日期
2006/12/5
期刊
Proceedings of the National Academy of Sciences
卷号
103
期号
49
页码范围
18656-18661
出版商
National Academy of Sciences
简介
Genomewide association studies depend on the extent of linkage disequilibrium (LD), the number and distribution of markers, and the underlying structure in populations under study. Outbreeding species generally exhibit limited LD, and consequently, a very large number of markers are required for effective whole-genome association genetic scans. In contrast, several of the world's major food crops are self-fertilizing inbreeding species with narrow genetic bases and theoretically extensive LD. Together these are predicted to result in a combination of low resolution and a high frequency of spurious associations in LD-based studies. However, inbred elite plant varieties represent a unique human-induced pseudooutbreeding population that has been subjected to strong selection for advantageous alleles. By assaying 1,524 genomewide SNPs we demonstrate that, after accounting for population substructure, the …
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N Rostoks, L Ramsay, K MacKenzie, L Cardle, PR Bhat… - Proceedings of the National Academy of Sciences, 2006