作者
Karolina A Aberg, Joseph L McClay, Srilaxmi Nerella, Shaunna Clark, Gaurav Kumar, Wenan Chen, Amit N Khachane, Linying Xie, Alexandra Hudson, Guimin Gao, Aki Harada, Christina M Hultman, Patrick F Sullivan, Patrik KE Magnusson, Edwin JCG Van Den Oord
发表日期
2014/3/1
期刊
JAMA psychiatry
卷号
71
期号
3
页码范围
255-264
出版商
American Medical Association
简介
Importance
Epigenetic studies present unique opportunities to advance schizophrenia research because they can potentially account for many of its clinical features and suggest novel strategies to improve disease management.
Objective
To identify schizophrenia DNA methylation biomarkers in blood.
Design, Setting, and Participants
The sample consisted of 759 schizophrenia cases and 738 controls (N = 1497) collected in Sweden. We used methyl-CpG–binding domain protein-enriched genome sequencing of the methylated genomic fraction, followed by next-generation DNA sequencing. We obtained a mean (SD) number of 68 (26.8) million reads per sample. This massive data set was processed using a specifically designed data analysis pipeline. Critical top findings from our methylome-wide association study (MWAS) were replicated in independent case-control participants using targeted pyrosequencing …
学术搜索中的文章
KA Aberg, JL McClay, S Nerella, S Clark, G Kumar… - JAMA psychiatry, 2014