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The observations by Abraham et al.(1), that P-glycoprotein and the cystic fibrosis transmembrane conductance regulator (CFTR) are associated with adenosine triphosphate (ATP) movement across the plasma membrane, have been supported by other studies using patch clamp and bulk ATP measurements of systems expressing CFTR (2, 3). On the other hand, Reddy et al.(4) and Li et al.(5) did not detect ATP channel activity with electrophysiological methods or with radioactive ATP in reconstituted vesicles that contain CFTR. They state that CFTR does not conduct ATP, but that it might act as a regulator of an associated channel or transport system for ATP, a possibility also raised by Al-Awqati (6) and Higgins (7).

Although there is conjecture that CFTR can form a complex with channels for anions (3) and cations (8), it is not excluded that CFTR and other ABC proteins are themselves directly involved in ATP …