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Several methods to estimate energy expenditure (EE) using body-worn sensors exist; however, quantifications of the differences in estimation error are missing. In this paper, we compare three prevalent EE estimation methods and five body locations to provide a basis for selecting among methods, sensors number, and positioning. We considered 1) counts-based estimation methods, 2) activity-specific estimation methods using METs lookup, and 3) activity-specific estimation methods using accelerometer features. The latter two estimation methods utilize subsequent activity classification and EE estimation steps. Furthermore, we analyzed accelerometer sensors number and on-body positioning to derive optimal EE estimation results during various daily activities. To evaluate our approach, we implemented a study with 15 participants that wore five accelerometer sensors while performing a wide range of sedentary …