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Variable response to docetaxel‐based neo‐adjuvant chemotherapy (NACT) in breast cancer patients had been reported. Genetic polymorphisms in the ABCB1 gene coding for the efflux transporter MDR1 (P‐glycoprotein, P‐gp) could result in altered tumour response. Hence, this study was proposed to assess the effect of single nucleotide polymorphisms (SNPs) of ABCB1 gene on tumour response in locally advanced breast cancer patients (LABC) of South India who have a distinct genetic makeup.

Out of 162 LABC patients recruited, 129 patients were included for the final analysis. DNA was extracted by “phenol‐chloroform extraction method” from the WBCs, and genotyping for SNPs rs1045642 (C3435T) and rs1128503 (C1236T) in ABCB1 gene was performed with real‐time PCR system using validated TaqMan^® SNP genotyping assay method. Tumour response was …