查看文章

In men, the long‐term consequences of low serum levels of sex steroids, vitamin D metabolites, and insulin‐like growth factor 1 (IGF‐1) on the evolution of muscle mass, muscle strength, or physical performance are unclear. Moreover, there are no data about the relationship between these hormones and incident sarcopenia defined as low muscle mass and function. The aim of this study was to determine whether the baseline levels of sex hormones, vitamin D metabolites, and IGF‐1 predict changes in muscle mass, muscle strength, physical performance, and incident sarcopenia.

In 518 men aged 40–79 years, recruited for participation in the European Male Ageing Study, total, free, and bioavailable testosterone (T), oestradiol (E), sex hormone‐binding globulin, IGF‐1, 25‐hydroxyvitamin D (25OHD), 1,25‐dihydroxyvitamin D (1,25(OH)₂D), and parathyroid hormone were assessed at …