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This study investigated the antioxidant properties of the fractions of the methanolic extract of Ocimum basilicum (OB) and their effects on the hematological parameters of acetaminophen-induced albino rats. Using vacuum liquid chromatography, the methanolic extract of OB was separated into four fractions (i, ii, iii, and iv) and studied using the DPPH and FRAP assays. Selected fractions ii and iv with the highest antioxidant activities for the animal study. Forty-two albino rats were divided into seven treatment groups (GP) of six animals each, subdivided into three replicates with two rats each. For seven days, rats in GP1 and GP2 were administered water and silymarin (1000 mg/kg), gave those in GP4 and GP5 500 mg/kg and 1000 mg/kg of fraction ii, respectively, while gave those in GP6 and GP7 500 mg/kg and 1000 mg/kg of fraction iv respectively. Rats in GP3 were administered 750 mg/kg of acetaminophen …