作者
Mainul Haque & Jaykaran Charan Siddhartha Dutta, Sayeeda Rahman, Rahnuma Ahmad, Tarun Kumar,Gitashree Dutta,Sudeshna Banerjee, Abdullahi Rabiu Abubakar, Adekunle Babajide Rowaiye, Sameer Dhingra, Velayutham Ravichandran, Santosh Kumar, Paras Sharma
发表日期
2021/11
期刊
Expert Review of Neurotherapeutics
出版商
Taylor & Francis
简介
Introduction
Dementia is a progressive neurodegenerative disorder impairing memory and cognition. Alzheimer’s Disease, followed by vascular dementia – the most typical form. Risk factors for vascular dementia include diabetes, cardiovascular disease, hyperlipidemia. Lipids’ levels are significantly associated with vascular changes in the brain.
Areas Covered
The present article reviews the cholesterol metabolism in the brain, which includes: the synthesis, transport, storage, and elimination process. Additionally, it reviews the role of cholesterol in the pathogenesis of dementia and statin as a therapeutic intervention in dementia. In addition to the above, it further reviews evidence in support of as well as against statin therapy in dementia, recent updates of statin pharmacology, and demerits of use of statin pharmacotherapy.
Expert Opinion
Amyloid-β peptides and intraneuronal neurofibrillary tangles are markers of …
学术搜索中的文章
S Dutta, S Rahman, R Ahmad, T Kumar, G Dutta… - Expert Review of Neurotherapeutics, 2021