作者
Saverio Stranges, James R Marshall, Raj Natarajan, Richard P Donahue, Maurizio Trevisan, Gerald F Combs, Francesco P Cappuccio, Antonio Ceriello, Mary E Reid
发表日期
2007/8/21
期刊
Annals of internal medicine
卷号
147
期号
4
页码范围
217-223
出版商
American College of Physicians
简介
Background
Findings from animal models suggest that selenium supplementation improves glucose metabolism.
Objective
To examine the effect of long-term selenium supplementation on the incidence of type 2 diabetes.
Design
Secondary analysis of a randomized, double-blind, placebo-controlled trial.
Setting
Areas of low selenium consumption of the eastern United States.
Patients
1202 persons seen in dermatology clinics who did not have type 2 diabetes at baseline.
Intervention
Oral administration of selenium, 200 μg/d, or placebo.
Measurements
Incidence of type 2 diabetes.
Results
During an average follow-up of 7.7 years (SD, 2.7), type 2 diabetes developed in 58 selenium …
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S Stranges, JR Marshall, R Natarajan, RP Donahue… - Annals of internal medicine, 2007