作者
John R Petrie, Nishi Chaturvedi, Ian Ford, Martijn CGJ Brouwers, Nicola Greenlaw, Therese Tillin, Irene Hramiak, Alun D Hughes, Alicia J Jenkins, Barbara EK Klein, Ronald Klein, Teik C Ooi, Peter Rossing, Coen DA Stehouwer, Naveed Sattar, Helen M Colhoun, H Nickerson, O Lou, S Dutta, J Haw, C Anderson, S Kean, E Thomson, L Gillespie, J Gibb, N Greenlaw, A Keech, A Jenkins, K March, S Williams, E Coady, M Bots, J Dreyer, T Jan, K Sheffy, R Lusky, S Peleg, A Shore, D Carty, P Donnan, M Witham, A Adler, E Lonn, P Rauchhaus, R Lindsay, M Brouwers, J Van-Melckebeke, T Hamill, L Cuthbertson, A Murray, L Jolly, E Miller, J Hair, A Bell, S Carmichael, E Douglas, P Surtees, E Dinnett, J Allan, C Watson, M McLaughlin, G Brindley, E Smillie, D Motherwell, S MacDonald, P Ellis, D Stuart, M Travers, S Brearley, L Greig, P Colman, A Nankervis, S Forulanos, D West, S Vaughan, M Bjorasen, J Donlan, J Vrazas, D O'Neal, J Horsburgh, H Pater, S Kent, S Twigg, G Fulcher, R Denner, A Piotrowicz, A Januszewski, A Coy, T Paul, C McDonald, S Tereschyn, N Schmidt, M Weingert, H Heard, S Burke, TC Ooi, H Lochnan, A Sorisky, E Keely, J Malcolm, J Maranger, C Favreau, S Petherick, K Boles, P Rossing, TW Hansen, S Lund, B Hemmingsen, N Thorogood, K Green, T Robinson, K Abouglilia, D Nayman, C Miller, R Warren, K Aizawa, M Balasubramani, S Toth, K Harvey, G Birch, S Atkin, T Sathyapalan, A James, Z Javed, J Wilding, B Martin, S Birch, A Wilcox, N Watson, N Oliver, N Jugnee, M Rutter, T Turgut, A Shaju, S Yau, S Subin, M Walker, D Wake, A Millward, P Chong, M Hibbert, J George, N Schaper, J Pinxt, J op het Roodt, Sam Phillips, L Murray, L Sleigh, A Collier, LE Sit
发表日期
2017/8/1
期刊
The lancet Diabetes & endocrinology
卷号
5
期号
8
页码范围
597-609
出版商
Elsevier
简介
Background
Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 diabetes, but whether it has cardiovascular benefits is unknown. We aimed to investigate whether metformin treatment (added to titrated insulin therapy) reduced atherosclerosis, as measured by progression of common carotid artery intima-media thickness (cIMT), in adults with type 1 diabetes at increased risk for cardiovascular disease.
Methods
REMOVAL was a double-blind, placebo-controlled trial undertaken at 23 hospital diabetes clinics in five countries (Australia, Canada, Denmark, the Netherlands, and the UK). Adults aged 40 years and older with type 1 diabetes of at least 5 years' duration and at least three of ten specific cardiovascular risk factors were randomly assigned (via an interactive voice response system) to oral metformin 1000 mg twice daily or placebo. Participants and site staff were masked to …
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JR Petrie, N Chaturvedi, I Ford, MCGJ Brouwers… - The lancet Diabetes & endocrinology, 2017