作者
Karen Hodgson, Katherine Tansey, Mojca Zvezdana Dernovšek, Joanna Hauser, Neven Henigsberg, Wolfgang Maier, Ole Mors, Anna Placentino, Marcella Rietschel, Daniel Souery, Rebecca Smith, Ian W Craig, Anne E Farmer, Katherine J Aitchison, Sarah Belsy, Oliver SP Davis, Rudolf Uher, Peter McGuffin
发表日期
2014/2/1
期刊
Journal of psychopharmacology
卷号
28
期号
2
页码范围
133-141
出版商
Sage Publications
简介
Aims
Antidepressant response varies between patients, possibly due to differences in the rate cytochrome P450 enzymes metabolise antidepressants into inactive compounds. Drug metabolism rates are influenced by common variants in the genes encoding these enzymes. However, it remains unclear whether treatment outcomes can be predicted by either CYP450 genotype or antidepressant serum concentration.
Methods
In GENDEP (a pharmacogenetic study of depressed individuals treated with either escitalopram or nortriptyline), serum concentrations of antidepressants and their primary metabolite were measured after eight weeks treatment and variants in CYP2D6 and CYP2C19 were genotyped.
Results
Amongst patients taking escitalopram (n=223), the genotype CYP2C19 was significantly associated with escitalopram serum concentrations and desmethylescitalopram:escitalopram ratio. For those taking …
学术搜索中的文章
K Hodgson, K Tansey, MZ Dernovšek, J Hauser… - Journal of psychopharmacology, 2014