作者
Matthew K Burrage, Andrew J Lewis, Jack J J Miller
发表日期
2023/4
来源
Cardiovascular Drugs and Therapy
卷号
37
期号
2
页码范围
379-399
出版商
Springer US
简介
Heart failure with preserved ejection fraction (HFpEF) is recognised as an increasingly prevalent, morbid and burdensome condition with a poor outlook. Recent advances in both the understanding of HFpEF and the technological ability to image cardiac function and metabolism in humans have simultaneously shone a light on the molecular basis of this complex condition of diastolic dysfunction, and the inflammatory and metabolic changes that are associated with it, typically in the context of a complex patient. This review both makes the case for an integrated assessment of the condition, and highlights that metabolic alteration may be a measurable outcome for novel targeted forms of medical therapy. It furthermore highlights how recent technological advancements and advanced medical imaging techniques have enabled the characterisation of the metabolism and function of HFpEF within patients, at rest and …
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MK Burrage, AJ Lewis, JJJ Miller - Cardiovascular Drugs and Therapy, 2023