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We propose a simple photonic crystal fiber (PCF) biosensor based on the surface plasmon resonance effect. The sensing properties are characterized using the finite element method. Chemically stable gold material is deposited on the outer surface of the PCF to realize the practical sensing approach. The performance of the modeled biosensor is investigated in terms of wavelength sensitivity, amplitude sensitivity, sensor resolution, and linearity of the resonant wavelength with the variation of structural parameters. In the sensing range of 1.33 to 1.37, maximum sensitivities of and are achieved with the high sensor resolutions of and using wavelength and amplitude interrogation methods, respectively. The designed biosensor will reduce fabrication complexity due to its simple and realistic hexagonal lattice structure. It is anticipated that the proposed biosensor may find …