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The development of highly-sensitive miniaturized sensors that allow real-time quantification of analytes is highly desirable in medical diagnostics, veterinary testing, food safety, and environmental monitoring. Photonic Crystal Fiber Surface Plasmon Resonance (PCF SPR) has emerged as a highly-sensitive portable sensing technology for testing chemical and biological analytes. PCF SPR sensing combines the advantages of PCF technology and plasmonics to accurately control the evanescent field and light propagation properties in single or multimode configurations. This review discusses fundamentals and fabrication of fiber optic technologies incorporating plasmonic coatings to rationally design, optimize and construct PCF SPR sensors as compared to conventional SPR sensing. PCF SPR sensors with selective metal coatings of fibers, silver nanowires, slotted patterns, and D-shaped structures for internal …