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We numerically demonstrate a surface plasmon resonance biosensor-based on dual-polarized spiral photonic crystal fiber (PCF). Chemically stable gold material is used as the active plasmonic material, which is placed on the outer layer of the PCF to facilitate practical fabrication. Finite-element method-based numerical investigations show that the proposed biosensor shows maximum wavelength sensitivity of 4600 and 4300 nm/RIU in x-and y-polarized modes at an analyte refractive index of 1.37. Moreover, for analyte refractive index ranging from 1.33 to 1.38, maximum amplitude sensitivities of 371.5 RIU ^-1 and 420.4 RIU ^-1 are obtained in xand y-polarized modes, respectively. In addition, the effects of changing pitch, different air hole diameter of the PCF and thickness of the gold layer on the sensing performance are also investigated. Owing to high sensitivity, improved sensing resolution and appropriate …