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To compare the reliability and stability of the multicomponent‐driven equilibrium single pulse observation of T₁ and T₂ (mcDESPOT) and Carl‐Purcell‐Meiboom‐Gill (CPMG) approaches to parameter estimation.

The stability and reliability of mcDESPOT and CPMG‐derived parameter estimates were compared through examination of energy surfaces, evaluation of model sloppiness, and Monte Carlo simulations. Comparisons were performed on an equal time basis and assuming a two‐component system. Parameter estimation bias, reflecting accuracy, and dispersion, reflecting precision, were derived for a range of signal‐to‐noise ratios (SNRs) and relaxation parameters.

The energy surfaces for parameters incorporated into the mcDESPOT signal model exhibit flatness, a complex structure of local minima, and instability to noise to a much greater extent than the corresponding …