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Over the last two decades, there has been an expeditious expansion in the generation and exploration of high-dimensional biomedical data. Identification of biomarkers from the genomics data poses a significant challenge in microarray data analysis. Therefore, for the methodical analysis of the genomics dataset, it is paramount to develop some effective algorithms. In this work, a multi-objective version of the emperor penguin optimization (EPO) algorithm with chaos, namely, multi-objective chaotic EPO (MOCEPO) is proposed. The suggested approach extends the original continuous single objective EPO to a competent binary multi-objective model. The objectives are to minimize the number of selected genes (NSG) and to maximize the classification accuracy (CA). In this work, Fisher score and minimum redundancy maximum relevance (mRMR) are independently used as initial filters. Further, the proposed …