作者
Jutamas Suwanpradid, Michael Shih, Lauren Pontius, Bin Yang, Anastasiya Birukova, Emma Guttman-Yasky, David L Corcoran, Loretta G Que, Robert M Tighe, Amanda S MacLeod
发表日期
2017/9/9
期刊
Journal of immunology (Baltimore, Md.: 1950)
卷号
199
期号
5
页码范围
1827
出版商
NIH Public Access
简介
The innate immune components that modulate allergic contact hypersensitivity (CHS) responses are poorly defined. Using human skin from contact dermatitis patients and a mouse model of CHS, we find that hapten allergens disrupt the Arginase1 (Arg1) and inducible nitric oxide synthase (iNOS or Nos2) dynamic in monocytes/macrophages, which renders those cells ineffectual in suppressing skin inflammation. Mice lacking Arg1 in macrophages develop increased CHS characterized by elevated ear thickening, monocytes/macrophage-dominated dermal inflammation, and increased iNOS and IL-6 expression compared to control mice. Treatment of Arg1 flox/flox; LysMCre+/− mice with a selective NOS inhibitor or knockout of iNOS significantly ameliorated CHS. Our findings suggest a critical role for Arg1 in monocytes/macrophages in suppressing CHS through dampening Nos2 expression. These results may …
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J Suwanpradid, M Shih, L Pontius, B Yang, A Birukova… - Journal of immunology (Baltimore, Md.: 1950), 2017