作者
Nicole G Campos, Emily A Burger, Stephen Sy, Monisha Sharma, Mark Schiffman, Ana Cecilia Rodriguez, Allan Hildesheim, Rolando Herrero, Jane J Kim
发表日期
2014/9/1
期刊
American journal of epidemiology
卷号
180
期号
5
页码范围
545-555
出版商
Oxford University Press
简介
Mathematical models of cervical cancer have been widely used to evaluate the comparative effectiveness and cost-effectiveness of preventive strategies. Major advances in the understanding of cervical carcinogenesis motivate the creation of a new disease paradigm in such models. To keep pace with the most recent evidence, we updated a previously developed microsimulation model of human papillomavirus (HPV) infection and cervical cancer to reflect 1) a shift towards health states based on HPV rather than poorly reproducible histological diagnoses and 2) HPV clearance and progression to precancer as a function of infection duration and genotype, as derived from the control arm of the Costa Rica Vaccine Trial (2004–2010). The model was calibrated leveraging empirical data from the New Mexico Surveillance, Epidemiology, and End Results Registry (1980–1999) and a state-of-the-art cervical cancer …
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NG Campos, EA Burger, S Sy, M Sharma, M Schiffman… - American journal of epidemiology, 2014