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This work reviews fundamentals and the recent state-of-art achievements in the field of plasmonic biosensing based terahertz (THz) spectroscopy. Being nonpoisonous and nondestructive to the human tissues, THz signals offer promising, cost-effective, and real-time biodevices for practical pharmacological applications such as enzyme reaction analysis. Rapid developments in the field of THz plasmonics biosensors and immunosensors have brought many methodologies to employ the resonant subwavelength structures operating based on the fundamental physics of multipoles and asymmetric lineshape resonances. In the ongoing hunt for new and advanced THz plasmonic biosensors, the toroidal metasensors have emerged as excellent alternates and are introduced to be a very promising technology for THz immunosensing applications. Here, we provide examples of recently proposed THz plasmonic …