作者
Shvetank Bhatt, Lakshman Puli, Chandragauda R Patil
发表日期
2021/3/1
来源
Drug discovery today
卷号
26
期号
3
页码范围
794-803
出版商
Elsevier Current Trends
简介
Highlights
- Oxidative stress is an etiopathogenic event upstream to Aβ-plaques and neurofibrillary tangles leading to Alzheimer’s disease.
- Unquenched ROS perturb the neuronal signaling, trigger pro-inflammatory pathways, and induce neuronal apoptosis/necrosis.
- Various innate and dietary anti-oxidants are emerging as anti-Alzheimer agents with marginal benefits.
The pathogenesis of Alzheimer’s disease (AD) involves neurodegeneration following the deposition of β-amyloid (Aβ) plaques and neurofibrillary tangles in vulnerable brain regions. The vulnerability of the brain to reactive oxygen species (ROS) is now emerging as a key detrimental factor driving AD pathogenesis. Oxidative stress (OS) irreversibly damages cellular biomolecules and perturbs neuronal functions. Scientific evidence is emerging that supports the therapeutic effects of antioxidants in preventing the onset and delaying the progression of AD …
学术搜索中的文章
S Bhatt, L Puli, CR Patil - Drug discovery today, 2021