作者
Eliana Rulli, Lorenzo Legramandi, Lorenzo Salvati, Mario Mandala
发表日期
2019/11/1
来源
Cancer
卷号
125
期号
21
页码范围
3776-3789
简介
Background
Targeted therapies (TT), combination immunotherapy (CMI), and monoimmunotherapy (MI) in combination with radiotherapy (CRI) or not are commonly used in patients with melanoma brain metastases, but studies that directly compare these strategies are lacking. The current meta‐analysis aimed to better elucidate their activity and efficacy.
Methods
A systematic search of MEDLINE, Embase, and conference proceedings up to January 2019 was performed to identify trials investigating combination TT, monotargeted TT (mono TT), MI, CMI, and CRI in melanoma brain metastases. The outcomes considered were progression‐free survival (PFS), overall survival (OS), and the objective response rate (ORR) as evaluated at both intracranial and extracranial sites. Random effects models were used to compare the different therapeutic strategies.
Results
A total of 15 trials were included that provided …
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E Rulli, L Legramandi, L Salvati, M Mandala - Cancer, 2019