作者
Subhasish Bose, Parasuram Krishnamoorthy, Ajay Varanasi, Jayamohan Nair, Mark Schutta, Seth Braunstein, Nayyar Iqbal, Stanley Schwartz, Caitlin St Clair, Stephen R Master, Daniel J Rader, Muredach P Reilly, Nehal N Mehta
发表日期
2013/1
期刊
Obesity
卷号
21
期号
1
页码范围
E118-E123
出版商
John Wiley & Sons, Inc.
简介
Objective
The association of plasma adipokines beyond waist circumference (WC) with coronary artery calcification (CAC), a measure of subclinical atherosclerosis, is unknown.
Design and Methods
Asymptomatic Caucasian individuals from two community‐based cross‐sectional studies (n = 1,285) were examined and multivariate analysis of traditional risk factors was performed, then WC and adipokines (adiponectin and leptin) were added. Incremental value of each was tested with likelihood ratio testing.
Results
Beyond traditional risk factors, WC (Tobit regression ratio 1.69, P < 0.001) and plasma leptin (1.57, P < 0.001) but not plasma adiponectin (P = 0.75) were independently associated with CAC. In nested models, neither adiponectin (χ2 = 0.76, P = 0.38) nor leptin (χ2 = 1.32, P = 0.25) added value to WC beyond traditional risk factors, whereas WC added incremental value to adiponectin (χ2 = 28.02, P < …
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S Bose, P Krishnamoorthy, A Varanasi, J Nair… - Obesity, 2013