作者
Alastair G Cardno, E Jane Marshall, Bina Coid, Alison M Macdonald, Tracy R Ribchester, Nadia J Davies, Piero Venturi, Lisa A Jones, Shôn W Lewis, Pak C Sham, Irving I Gottesman, Anne E Farmer, Peter McGuffin, Adrianne M Reveley, Robin M Murray
发表日期
1999/2/1
期刊
Archives of general psychiatry
卷号
56
期号
2
页码范围
162-168
出版商
American Medical Association
简介
Background
Previous twin studies have supported a genetic contribution to the major categories of psychotic disorders, but few of these have employed operational diagnostic criteria, and no such study has been based on a sample that included the full range of functional psychotic disorders.
Methods
A total of 224 twin probands (106 monozygotic, 118 dizygotic) with a same-sex co-twin and a lifetime history of psychosis was ascertained from the service-based Maudsley Twin Register in London, England. Research Diagnostic Criteria psychotic diagnoses were made on a lifetime-ever basis. Main-lifetime diagnoses ofDSM-III-RandInternational Statistical Classification of Diseases, 10th Revisionschizophrenia were also made. Probandwise concordance rates and correlations in liability were calculated, and biometrical model fitting applied.
Results
A substantial genetic contribution to variance in liability was confirmed …
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AG Cardno, EJ Marshall, B Coid, AM Macdonald… - Archives of general psychiatry, 1999