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Climate change could strongly affect the wheat crop that accounts for 21% of food and 200 million hectares of farmland worldwide. This article reviews some of the approaches for addressing the expected effects that climate change may likely inflict on wheat in some of the most important wheat growing areas, namely germplasm adaptation, system management, and mitigation. Future climate scenarios suggest that global warming may be beneficial for the wheat crop in some regions, but could reduce productivity in zones where optimal temperatures already exist. For example, by 2050, as a result of possible climate shifts in the Indo-Gangetic Plains (IGPs) – currently part of the favorable, high potential, irrigated, low rainfall mega-environment, which accounts for 15% of global wheat production – as much as 51% of its area might be reclassified as a heat-stressed, irrigated, short-season production mega …