作者
Jean-Michel Pawlotsky, Georgios Germanidis, Pierre-Olivier Frainais, Magali Bouvier, Alexandre Soulier, Muriel Pellerin, Daniel Dhumeaux
发表日期
1999/8/1
期刊
Journal of virology
卷号
73
期号
8
页码范围
6490-6499
出版商
American Society for Microbiology
简介
Sustained hepatitis C virus (HCV) RNA clearance is achieved in 8 to 12% of patients with chronic HCV infection treated with alpha interferon (IFN-α) at the approved dose of 3 MU three times a week for 6 months and in about 25% of those receiving this treatment for 12 months. We used single-strand conformation polymorphism analysis combined with cloning and sequencing strategies to characterize the genetic evolution of HCV second envelope gene hypervariable region 1 (HVR1) quasispecies during and after IFN therapy in patients who failed to clear HCV RNA. Sustained HCV RNA clearance was achieved in 6% of patients. Profound changes in HVR1 quasispecies major variants were estimated to occur in 70% of the patients during and after therapy. These changes were evolutionary and were characterized by shifts in the virus population, related to selection and subsequent diversification of minor …
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JM Pawlotsky, G Germanidis, PO Frainais, M Bouvier… - Journal of virology, 1999