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River Hindon is a major source of water to the highly populated and predominantly rural population of western Uttar Pradesh, India. The main goal of the present study was to assess the impact of urban and industrial activities on the water quality of river Hindon at the Ghaziabad. For this, river water samples were collected from six different sites all along the route of Hindon main streamline and its branch and were analyzed for pH, turbidity, electrical conductivity (EC), total dissolved solids (TDS), total alkalinity (TA), total hardness (TH) and calcium hardness (Ca-H), chemical oxygen (COD) demand, biochemical oxygen demand (BOD), dissolved oxygen (D.O.), sulphate (as SO₄ ^2 −), nitrate (as NO₃ ⁻) and chloride (Cl⁻) levels. There were drastic variations for EC (0.83–5.04 ms), turbidity (28.7–109.3 NTU), TDS (222.2–2426.3 mg l^− 1), SO₄ (36.4–162.4 mg l^− 1), NO₃ …