作者
Moira Marizzoni, Clarissa Ferrari, Claudio Babiloni, Diego Albani, Frederik Barkhof, Libera Cavaliere, Mira Didic, Gianluigi Forloni, Federica Fusco, Samantha Galluzzi, Tilman Hensch, Jorge Jovicich, Camillo Marra, José Luis Molinuevo, Flavio Nobili, Lucilla Parnetti, Pierre Payoux, Jean-Philippe Ranjeva, Federica Ribaldi, Elena Rolandi, Paolo Maria Rossini, Marco Salvatore, Andrea Soricelli, Magda Tsolaki, Pieter Jelle Visser, Jens Wiltfang, Jill C Richardson, Régis Bordet, Olivier Blin, Giovanni B Frisoni
发表日期
2020/5/1
期刊
Neurobiology of aging
卷号
89
页码范围
55-62
出版商
Elsevier
简介
Amyloid and tau pathological accumulation should be considered for Alzheimer's disease (AD) definition and before subjects' enrollment in disease-modifying trials. Although age, APOEε4, and sex influence cerebrospinal fluid (CSF) biomarker levels, none of these variables are considered by current normality/abnormality cutoffs. Using baseline CSF data from 2 independent cohorts (PharmaCOG/European Alzheimer's Disease Neuroimaging Initiative and Alzheimer's Disease Neuroimaging Initiative), we investigated the effect of age, APOEε4 status, and sex on CSF Aβ42/P-tau distribution and cutoff extraction by applying mixture models with covariates. The Aβ42/P-tau distribution revealed the presence of 3 subgroups (AD-like, intermediate, control-like) and 2 cutoffs. The identification of the intermediate subgroup and of the higher cutoff was APOEε4 dependent in both cohorts. APOE-specific classification (higher …
学术搜索中的文章
M Marizzoni, C Ferrari, C Babiloni, D Albani, F Barkhof… - Neurobiology of aging, 2020