作者
Helmut Wittkowski, Keiichi Hirono, Fukiko Ichida, Thomas Vogl, Fei Ye, Xing Yanlin, Kazuyoshi Saito, Keiichiro Uese, Toshio Miyawaki, Dorothee Viemann, Johannes Roth, Dirk Foell
发表日期
2007/12
期刊
Arthritis & Rheumatism: Official Journal of the American College of Rheumatology
卷号
56
期号
12
页码范围
4174-4181
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
Receptor for advanced glycation end products (RAGE) serves as a pattern recognition receptor for several endogenous ligands that are potent inducers of inflammation. By activating endothelial cells and leukocytes, RAGE augments recruitment of leukocytes to sites of inflammation, which is a key process, especially in vasculitis. Soluble RAGE (sRAGE) acts as a naturally occurring inhibitor of RAGE by neutralizing proinflammatory ligands, e.g., S100A12. This neutrophil‐derived protein has been reported to be associated with Kawasaki disease (KD) and to provoke proinflammatory responses. The aim of this study was to investigate circulating sRAGE in an acute inflammatory disorder and to compare these data directly with concentrations of the proinflammatory RAGE ligand S100A12.
Methods
Serum concentrations of sRAGE and S100A12 were analyzed by specific enzyme‐linked immunosorbent …
学术搜索中的文章
H Wittkowski, K Hirono, F Ichida, T Vogl, F Ye, X Yanlin… - Arthritis & Rheumatism: Official Journal of the American …, 2007