作者
Ofer Zimmerman, Maxwell I Zimmerman, Saravanan Raju, Christopher A Nelson, John M Errico, Emily A Madden, Autumn C Holmes, Ahmed O Hassan, Laura A VanBlargan, Arthur S Kim, Lucas J Adams, Katherine Basore, Bradley M Whitener, Sathvik Palakurty, Hannah G Davis-Adams, Chengqun Sun, Theron Gilliland, James T Earnest, Hongming Ma, Gregory D Ebel, Christian Zmasek, Richard H Scheuermann, William B Klimstra, Daved H Fremont, Michael S Diamond
发表日期
2023/10/26
期刊
Cell
卷号
186
期号
22
页码范围
4818-4833. e25
出版商
Elsevier
简介
MXRA8 is a receptor for chikungunya (CHIKV) and other arthritogenic alphaviruses with mammalian hosts. However, mammalian MXRA8 does not bind to alphaviruses that infect humans and have avian reservoirs. Here, we show that avian, but not mammalian, MXRA8 can act as a receptor for Sindbis, western equine encephalitis (WEEV), and related alphaviruses with avian reservoirs. Structural analysis of duck MXRA8 complexed with WEEV reveals an inverted binding mode compared with mammalian MXRA8 bound to CHIKV. Whereas both domains of mammalian MXRA8 bind CHIKV E1 and E2, only domain 1 of avian MXRA8 engages WEEV E1, and no appreciable contacts are made with WEEV E2. Using these results, we generated a chimeric avian-mammalian MXRA8 decoy-receptor that neutralizes infection of multiple alphaviruses from distinct antigenic groups in vitro and in vivo. Thus, different …
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