作者
Rita E Chen, Brittany K Smith, John M Errico, David N Gordon, Emma S Winkler, Laura A VanBlargan, Chandni Desai, Scott A Handley, Kimberly A Dowd, M Jane Cardosa, Carlos A Sariol, Esper G Kallas, Rafick-Pierre Sékaly, Nikos Vasilakis, Daved H Fremont, Stephen S Whitehead, Theodore C Pierson, Michael S Diamond
发表日期
2021/11/10
期刊
Cell host & microbe
卷号
29
期号
11
页码范围
1634-1648. e5
出版商
Elsevier
简介
Although divergent dengue viruses (DENVs) have been isolated in insects, nonhuman primates, and humans, their relationships to the four canonical serotypes (DENV 1–4) are poorly understood. One virus isolated from a dengue patient, DKE-121, falls between genotype and serotype levels of sequence divergence to DENV-4. To examine its antigenic relationship to DENV-4, we assessed serum neutralizing and protective activity. Whereas DENV-4-immune mouse sera neutralize DKE-121 infection, DKE-121-immune sera inhibit DENV-4 less efficiently. Passive transfer of DENV-4 or DKE-121-immune sera protects mice against homologous, but not heterologous, DENV-4 or DKE-121 challenge. Antigenic cartography suggests that DENV-4 and DKE-121 are related but antigenically distinct. However, DENV-4 vaccination confers protection against DKE-121 in nonhuman primates, and serum from humans …
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RE Chen, BK Smith, JM Errico, DN Gordon, ES Winkler… - Cell host & microbe, 2021