作者
JMA Van Den Brand, Bart L Haagmans, Lonneke Leijten, Debby van Riel, Byron EE Martina, ADME Osterhaus, Thijs Kuiken
发表日期
2008/7
期刊
Veterinary pathology
卷号
45
期号
4
页码范围
551-562
出版商
SAGE Publications
简介
The pathology of severe acute respiratory syndrome-coronavirus (SARS-CoV) infection in cats and ferrets is poorly described, and the distribution of angiotensin-converting enzyme 2 (ACE2), a receptor for SARS-CoV, in the respiratory tracts of these species is unknown. We observed SARS-CoV antigen expression and lesions in the respiratory tracts of 4 cats and 4 ferrets at 4 days postinoculation and ACE2 expression in the respiratory tracts of 3 cats and 3 ferrets without infection. All infected cats and ferrets had diffuse alveolar damage associated with SARS-CoV antigen expression. A novel SARS-CoV-associated lesion was tracheo-bronchoadenitis in cats. SARS-CoV antigen expression occurred mainly in type I and II pneumocytes and serous cells of tracheo-bronchial submucosal glands of cats and in type II pneumocytes of ferrets. ACE2 expression occurred mainly in type I and II pneumocytes, tracheo …
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JMA Van Den Brand, BL Haagmans, L Leijten… - Veterinary pathology, 2008