作者
Widagdo Widagdo, V Stalin Raj, Debby Schipper, Kimberley Kolijn, Geert JLH Van Leenders, Berend J Bosch, Albert Bensaid, Joaquim Segalés, Wolfgang Baumgärtner, Albert DME Osterhaus, Marion P Koopmans, Judith MA Van Den Brand, Bart L Haagmans
发表日期
2016/5/1
期刊
Journal of virology
卷号
90
期号
9
页码范围
4838-4842
出版商
American Society for Microbiology
简介
Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor—dipeptidyl peptidase 4 (DPP4)—is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.
学术搜索中的文章
W Widagdo, VS Raj, D Schipper, K Kolijn… - Journal of virology, 2016