作者
Gioacchino Tedeschi, L Lavorgna, P Russo, A Prinster, D Dinacci, G Savettieri, A Quattrone, Paolo Livrea, C Messina, A Reggio, Vincenzo Bresciamorra, Giuseppe Orefice, M Paciello, Arturo Brunetti, G Coniglio, Simona Bonavita, Alfonso Di Costanzo, A Bellacosa, P Valentino, M Quarantelli, F Patti, G Salemi, E Cammarata, Isabella Laura Simone, Marco Salvatore, Vincenzo Bonavita, B Alfano
发表日期
2005/7/26
期刊
Neurology
卷号
65
期号
2
页码范围
280-285
出版商
Lippincott Williams & Wilkins
简介
Objective: To measure white matter (WM) and gray matter (GM) atrophy and lesion load in a large population of patients with multiple sclerosis (MS) using a fully automated, operator-independent, multiparametric segmentation method.
Methods: The study population consisted of 597 patients with MS and 104 control subjects. The MRI parameters were abnormal WM fraction (AWM-f), global WM-f (gWM-f), and GM fraction (GM-f).
Results: Significant differences between patients with MS and control subjects included higher AWM-f and reduced gWM-f and GM-f. MRI data showed significant differences between patients with relapsing-remitting and secondary progressive forms of MS. Significant correlations between MRI parameters and between MRI and clinical data were found.
Conclusions: Patients with multiple sclerosis have significant atrophy of both white matter (WM) and gray matter (GM …
引用总数
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