作者
Ashwin N Ananthakrishnan, Andrew Cagan, Vivian S Gainer, Tianxi Cai, Su-Chun Cheng, Guergana Savova, Pei Chen, Peter Szolovits, Zongqi Xia, Philip L De Jager, Stanley Y Shaw, Susanne Churchill, Elizabeth W Karlson, Isaac Kohane, Robert M Plenge, Shawn N Murphy, Katherine P Liao
发表日期
2013/8/1
期刊
Inflammatory bowel diseases
卷号
19
期号
9
页码范围
1921-1927
出版商
Oxford University Press
简介
Background
Vitamin D may have an immunologic role in Crohn’s disease (CD) and ulcerative colitis (UC). Retrospective studies suggested a weak association between vitamin D status and disease activity but have significant limitations.
Methods
Using a multi-institution inflammatory bowel disease cohort, we identified all patients with CD and UC who had at least one measured plasma 25-hydroxy vitamin D (25(OH)D). Plasma 25(OH)D was considered sufficient at levels ≥30 ng/mL. Logistic regression models adjusting for potential confounders were used to identify impact of measured plasma 25(OH)D on subsequent risk of inflammatory bowel disease–related surgery or hospitalization. In a subset of patients where multiple measures of 25(OH)D were available, we examined impact of normalization of vitamin D status on study outcomes.
Results
Our study …
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AN Ananthakrishnan, A Cagan, VS Gainer, T Cai… - Inflammatory bowel diseases, 2013