作者
Patrick Champagne, Graham S Ogg, Abigail S King, Christian Knabenhans, Kim Ellefsen, Massimo Nobile, Victor Appay, G Paolo Rizzardi, Sylvain Fleury, Martin Lipp, Reinhold Förster, Sarah Rowland-Jones, Rafick-P Sékaly, Andrew J McMichael, Giuseppe Pantaleo
发表日期
2001/3/1
期刊
Nature
卷号
410
期号
6824
页码范围
106-111
出版商
Nature Publishing Group UK
简介
Understanding the lineage differentiation of memory T cells is a central question in immunology. We investigated this issue by analysing the expression of the chemokine receptor CCR7, which defines distinct subsets of naive and memory T lymphocytes with different homing and effector capacities,, and antiviral immune responses to HIV and cytomegalovirus. Ex vivo analysis of the expression of CD45RA and CCR7 antigens, together with in vitro analysis of the cell-division capacity of different memory CD8+ T-cell populations, identified four subsets of HIV- and CMV-specific CD8+ T lymphocytes, and indicated the following lineage differentiation pattern: CD45RA+CCR7+ → CD45RA-CCR7+ → CD45RACD45RA-CCR7- → CD45RA+CCR7-. Here we demonstrate through analysis of cell division (predominantly restricted to the CCR7+CD8+ T-cell subsets) that the differentiation of antigen-specific CD8+ T cells is a …
引用总数
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P Champagne, GS Ogg, AS King, C Knabenhans… - Nature, 2001