作者
Maria Tolia, Anna Zygogianni, John R Kouvaris, Christos Meristoudis, Niki Margari, Petros Karakitsos, Ioannis Kokakis, Dimitrios Kardamakis, Christos Papadimitriou, Kyriaki Mystakidou, Nikolaos Tsoukalas, George Kyrgias, Basil Armonis, Dimitrios K Filippiadis, Alexios D Kelekis, Nikolaos Kelekis, Vasileios Kouloulias
发表日期
2014/1/1
来源
Anticancer research
卷号
34
期号
1
页码范围
23-37
出版商
International Institute of Anticancer Research
简介
The present review aims at providing an assessment of the clinical significance of Biphosphonates (BPs) in the treatment of patients with cancer.
Materials and Methods
A systematic literature review was performed based on database search in PubMed/Medline and included articles up to August 2013. Results
BPs can reduce, delay, and prevent complications related to bone metastases. They improve mobility, functionality, pain, and quality of life. They limit survival of any inactive cancer cells in the microenvironment of the bone marrow, contributing to their death from anti-neoplastic treatments. Moreover, they limit and delay bone morbidity due to osteoporosis related to hormonotherapy in breast and prostate cancer. Finally, benefits can be derived from the combination of BPs with radiotherapy in bone density, recalcification, opioid use, and patient's quality of life and performance status. Conclusion
The …学术搜索中的文章
M Tolia, A Zygogianni, JR Kouvaris, C Meristoudis… - Anticancer research, 2014