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To the Editor: I would like to thank Papaioannou et al [1] for highlighting some technological and clinical issues that could help with the interpretation of the results from our study [2]. They mention that the technological differences between the continuous glucose monitoring (CGM) systems (ie flash glucose monitoring and real-time CGM) could explain the reason behind the conflicting evidence. As mentioned in our study, subgroup analyses stratified according to the various CGM systems were conducted and the analyses reported no significant subgroup difference (p= 0.88)(ESM Fig. 4 in our original paper [2]). In other words, the difference in CGM systems is not a significant covariate to the effectiveness of CGM in maintaining glycaemic control compared with selfmonitoring of blood glucose (SMBG). Papaioannou et al also mention the self-monitoring frequency of flash glucose monitoring in relation to glycaemic …