作者
Ao Chen, Yidi Sun, Ying Lei, Chao Li, Sha Liao, Juan Meng, Yiqin Bai, Zhen Liu, Zhifeng Liang, Zhiyong Zhu, Nini Yuan, Hao Yang, Zihan Wu, Feng Lin, Kexin Wang, Mei Li, Shuzhen Zhang, Meisong Yang, Tianyi Fei, Zhenkun Zhuang, Yiming Huang, Yong Zhang, Yuanfang Xu, Luman Cui, Ruiyi Zhang, Lei Han, Xing Sun, Bichao Chen, Wenjiao Li, Baoqian Huangfu, Kailong Ma, Jianyun Ma, Zhao Li, Yikun Lin, He Wang, Yanqing Zhong, Huifang Zhang, Qian Yu, Yaqian Wang, Xing Liu, Jian Peng, Chuanyu Liu, Wei Chen, Wentao Pan, Yingjie An, Shihui Xia, Yanbing Lu, Mingli Wang, Xinxiang Song, Shuai Liu, Zhifeng Wang, Chun Gong, Xin Huang, Yue Yuan, Yun Zhao, Qinwen Chai, Xing Tan, Jianfeng Liu, Mingyuan Zheng, Shengkang Li, Yaling Huang, Yan Hong, Zirui Huang, Min Li, Mengmeng Jin, Yan Li, Hui Zhang, Suhong Sun, Li Gao, Yinqi Bai, Mengnan Cheng, Guohai Hu, Shiping Liu, Bo Wang, Bin Xiang, Shuting Li, Huanhuan Li, Mengni Chen, Shiwen Wang, Minglong Li, Weibin Liu, Xin Liu, Qian Zhao, Michael Lisby, Jing Wang, Jiao Fang, Yun Lin, Qing Xie, Jie He, Huatai Xu, Wei Huang, Jan Mulder, Huanming Yang, Yangang Sun, Mathias Uhlen, Muming Poo, Jian Wang, Jianhua Yao, Wu Wei, Yuxiang Li, Zhiming Shen, Longqi Liu, Zhiyong Liu, Xun Xu, Chengyu Li
发表日期
2023/8/17
期刊
Cell
卷号
186
期号
17
页码范围
3726-3743. e24
出版商
Elsevier
简介
Elucidating the cellular organization of the cerebral cortex is critical for understanding brain structure and function. Using large-scale single-nucleus RNA sequencing and spatial transcriptomic analysis of 143 macaque cortical regions, we obtained a comprehensive atlas of 264 transcriptome-defined cortical cell types and mapped their spatial distribution across the entire cortex. We characterized the cortical layer and region preferences of glutamatergic, GABAergic, and non-neuronal cell types, as well as regional differences in cell-type composition and neighborhood complexity. Notably, we discovered a relationship between the regional distribution of various cell types and the region's hierarchical level in the visual and somatosensory systems. Cross-species comparison of transcriptomic data from human, macaque, and mouse cortices further revealed primate-specific cell types that are enriched in layer 4, with …
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