作者
Arthur Kocher, Luka Papac, Rodrigo Barquera, Felix M Key, Maria A Spyrou, Ron Hübler, Adam B Rohrlach, Franziska Aron, Raphaela Stahl, Antje Wissgott, Florian Van Bömmel, Maria Pfefferkorn, Alissa Mittnik, Vanessa Villalba-Mouco, Gunnar U Neumann, Maïté Rivollat, Marieke S van de Loosdrecht, Kerttu Majander, Rezeda I Tukhbatova, Lyazzat Musralina, Ayshin Ghalichi, Sandra Penske, Susanna Sabin, Megan Michel, Joscha Gretzinger, Elizabeth A Nelson, Tiago Ferraz, Kathrin Nägele, Cody Parker, Marcel Keller, Evelyn K Guevara, Michal Feldman, Stefanie Eisenmann, Eirini Skourtanioti, Karen Giffin, Guido Alberto Gnecchi-Ruscone, Susanne Friederich, Vittoria Schimmenti, Valery Khartanovich, Marina K Karapetian, Mikhail S Chaplygin, Vladimir V Kufterin, Aleksandr A Khokhlov, Andrey A Chizhevsky, Dmitry A Stashenkov, Anna F Kochkina, Cristina Tejedor-Rodríguez, Íñigo García-Martínez de Lagrán, Héctor Arcusa-Magallón, Rafael Garrido-Pena, José Ignacio Royo-Guillén, Jan Nováček, Stéphane Rottier, Sacha Kacki, Sylvie Saintot, Elena Kaverzneva, Andrej B Belinskiy, Petr Velemínský, Petr Limburský, Michal Kostka, Louise Loe, Elizabeth Popescu, Rachel Clarke, Alice Lyons, Richard Mortimer, Antti Sajantila, Yadira Chinique de Armas, Silvia Teresita Hernandez Godoy, Diana I Hernández-Zaragoza, Jessica Pearson, Didier Binder, Philippe Lefranc, Anatoly R Kantorovich, Vladimir E Maslov, Luca Lai, Magdalena Zoledziewska, Jessica F Beckett, Michaela Langová, Alžběta Danielisová, Tara Ingman, Gabriel García Atiénzar, Maria Paz de Miguel Ibáñez, Alejandro Romero, Alessandra Sperduti, Sophie Beckett, Susannah J Salter, Emma D Zilivinskaya, Dmitry V Vasil’ev, Kristin von Heyking, Richard L Burger, Lucy C Salazar, Luc Amkreutz, Masnav Navruzbekov, Eva Rosenstock, Carmen Alonso-Fernández, Vladimir Slavchev, Alexey A Kalmykov, Biaslan Ch Atabiev, Elena Batieva, Micaela Alvarez Calmet, Bastien Llamas, Michael Schultz, Raiko Krauß, Javier Jiménez-Echevarría, Michael Francken, Svetlana Shnaider, Peter de Knijff, Eveline Altena, Katrien Van de Vijver, Lars Fehren-Schmitz, Tiffiny A Tung, Sandra Lösch, Maria Dobrovolskaya, Nikolaj Makarov, Chris Read, Melanie Van Twest, Claudia Sagona, Peter C Ramsl, Murat Akar, K Aslihan Yener, Eduardo Carmona Ballestero, Francesco Cucca, Vittorio Mazzarello, Pilar Utrilla, Kurt Rademaker, Eva Fernández-Domínguez, Douglas Baird, Patrick Semal, Lourdes Márquez-Morfín, Mirjana Roksandic, Hubert Steiner, Domingo Carlos Salazar-García, Natalia Shishlina, Yilmaz Selim Erdal, Fredrik Hallgren, Yavor Boyadzhiev, Kamen Boyadzhiev, Mario Küßner, Duncan Sayer, Päivi Onkamo, Robin Skeates, Manuel Rojo-Guerra, Alexandra Buzhilova, Elmira Khussainova, Leyla B Djansugurova, Arman Z Beisenov, Zainolla Samashev, Ken Massy, Marcello Mannino, Vyacheslav Moiseyev
发表日期
2021/10/8
期刊
Science
卷号
374
期号
6564
页码范围
182-188
出版商
American Association for the Advancement of Science
简介
Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.
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A Kocher, L Papac, R Barquera, FM Key, MA Spyrou… - Science, 2021