作者
Amin Haghani, Caesar Z Li, Todd R Robeck, Joshua Zhang, Ake T Lu, Julia Ablaeva, Victoria A Acosta-Rodríguez, Danielle M Adams, Abdulaziz N Alagaili, Javier Almunia, Ajoy Aloysius, Nabil MS Amor, Reza Ardehali, Adriana Arneson, C Scott Baker, Gareth Banks, Katherine Belov, Nigel C Bennett, Peter Black, Daniel T Blumstein, Eleanor K Bors, Charles E Breeze, Robert T Brooke, Janine L Brown, Gerald Carter, Alex Caulton, Julie M Cavin, Lisa Chakrabarti, Ioulia Chatzistamou, Andreas S Chavez, Hao Chen, Kaiyang Cheng, Priscila Chiavellini, Oi-Wa Choi, Shannon Clarke, Joseph A Cook, Lisa N Cooper, Marie-Laurence Cossette, Joanna Day, Joseph DeYoung, Stacy Dirocco, Christopher Dold, Jonathan L Dunnum, Erin E Ehmke, Candice K Emmons, Stephan Emmrich, Ebru Erbay, Claire Erlacher-Reid, Chris G Faulkes, Zhe Fei, Steven H Ferguson, Carrie J Finno, Jennifer E Flower, Jean-Michel Gaillard, Eva Garde, Livia Gerber, Vadim N Gladyshev, Rodolfo G Goya, Matthew J Grant, Carla B Green, M Bradley Hanson, Daniel W Hart, Martin Haulena, Kelsey Herrick, Andrew N Hogan, Carolyn J Hogg, Timothy A Hore, Taosheng Huang, Juan Carlos Izpisua Belmonte, Anna J Jasinska, Gareth Jones, Eve Jourdain, Olga Kashpur, Harold Katcher, Etsuko Katsumata, Vimala Kaza, Hippokratis Kiaris, Michael S Kobor, Pawel Kordowitzki, William R Koski, Michael Krützen, Soo Bin Kwon, Brenda Larison, Sang-Goo Lee, Marianne Lehmann, Jean-François Lemaître, Andrew J Levine, Xinmin Li, Cun Li, Andrea R Lim, David TS Lin, Dana M Lindemann, Schuyler W Liphardt, Thomas J Little, Nicholas Macoretta, Dewey Maddox, Craig O Matkin, Julie A Mattison, Matthew McClure, June Mergl, Jennifer J Meudt, Gisele A Montano, Khyobeni Mozhui, Jason Munshi-South, William J Murphy, Asieh Naderi, Martina Nagy, Pritika Narayan, Peter W Nathanielsz, Ngoc B Nguyen, Christof Niehrs, Batsaikhan Nyamsuren, Justine K O’Brien, Perrie O’Tierney Ginn, Duncan T Odom, Alexander G Ophir, Steve Osborn, Elaine A Ostrander, Kim M Parsons, Kimberly C Paul, Amy B Pedersen, Matteo Pellegrini, Katharina J Peters, Jessica L Petersen, Darren W Pietersen, Gabriela M Pinho, Jocelyn Plassais, Jesse R Poganik, Natalia A Prado, Pradeep Reddy, Benjamin Rey, Beate R Ritz, Jooke Robbins, Magdalena Rodriguez, Jennifer Russell, Elena Rydkina, Lindsay L Sailer, Adam B Salmon, Akshay Sanghavi, Kyle M Schachtschneider, Dennis Schmitt, Todd Schmitt, Lars Schomacher, Lawrence B Schook, Karen E Sears, Ashley W Seifert, Aaron BA Shafer, Anastasia V Shindyapina, Melanie Simmons, Kavita Singh
发表日期
2023/8/11
期刊
Science
卷号
381
期号
6658
页码范围
eabq5693
出版商
American Association for the Advancement of Science
简介
Using DNA methylation profiles (n = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervised clustering across all samples, we identified 55 distinct cytosine modules, of which 30 are related to traits such as maximum life span, adult weight, age, sex, and human mortality risk. Maximum life span is associated with methylation levels in HOXL subclass homeobox genes and developmental processes and is potentially regulated by pluripotency transcription factors. The methylation state of some modules responds to perturbations such as caloric restriction, ablation of growth hormone receptors, consumption of high-fat diets, and expression of Yamanaka factors. This study reveals an intertwined evolution of the genome and epigenome that mediates the biological characteristics and traits of different mammalian species.
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