作者
N Bhala, J Emberson, A Merhi, S Abramson, N Arber, JA Baron, C Bombardier, C Cannon, ME Farkouh, GA FitzGerald, P Goss, H Halls, E Hawk, C Hawkey, C Hennekens, M Hochberg, LE Holland, PM Kearney, L Laine, A Lanas, P Lance, A Laupacis, J Oates, Carlo Patrono, TJ Schnitzer, S Solomon, P Tugwell, K Wilson, J Wittes, C Baigent
发表日期
2013/5/30
期刊
Lancet (London, England)
卷号
382
期号
9894
页码范围
769-779
简介
Background
The vascular and gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors (coxibs) and traditional non-steroidal anti-inflammatory drugs (tNSAIDs), are not well characterised, particularly in patients at increased risk of vascular disease. We aimed to provide such information through meta-analyses of randomised trials.
Methods
We undertook meta-analyses of 280 trials of NSAIDs versus placebo (124,513 participants, 68,342 person-years) and 474 trials of one NSAID versus another NSAID (229,296 participants, 165,456 person-years). The main outcomes were major vascular events (non-fatal myocardial infarction, non-fatal stroke, or vascular death); major coronary events (non-fatal myocardial infarction or coronary death); stroke; mortality; heart failure; and upper gastrointestinal complications (perforation, obstruction, or bleed).
学术搜索中的文章
N Bhala, J Emberson, A Merhi, S Abramson, N Arber… - Lancet (London, England), 2013