作者
James A De Lemos, David A Morrow, Jane H Bentley, Torbjørn Omland, Marc S Sabatine, Carolyn H McCabe, Christian Hall, Christopher P Cannon, Eugene Braunwald
发表日期
2001/10/4
期刊
New England Journal of Medicine
卷号
345
期号
14
页码范围
1014-1021
出版商
Massachusetts Medical Society
简介
Background
Brain (B-type) natriuretic peptide is a neurohormone synthesized predominantly in ventricular myocardium. Although the circulating level of this neurohormone has been shown to provide independent prognostic information in patients with transmural myocardial infarction, few data are available for patients with acute coronary syndromes in the absence of ST-segment elevation.
Methods
We measured B-type natriuretic peptide in plasma specimens obtained a mean (±SD) of 40±20 hours after the onset of ischemic symptoms in 2525 patients from the Orbofiban in Patients with Unstable Coronary Syndromes–Thrombolysis in Myocardial Infarction 16 study.
Results
The base-line level of B-type natriuretic peptide was correlated with the risk of death, heart failure, and myocardial infarction at 30 days and 10 months. The unadjusted rate of death increased in a stepwise fashion among patients in …
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